ESPN 51th Annual Meeting

ESPN 2018


 
Cardiovascular risk factors in children after kidney transplantation
INA KAZYRA 1 MOHSEN HOSHYARIKHANI 1 FARIDA FOTOVATKASBSHIRAZI 1 TATJANA CHABATAROVA 1

1- BELARUS STATE MEDICAL UNIVERSITY
 
Introduction:

Kidney transplantation(Tx)is the gold standard treatment for many patients with end stage renal disease(ESRD).Renal transplant recipients (RTRs) are at increased risk of cardiovascular(CV)events.The aim of our study is to evaluate early CV changes in children after Tx.

Material and methods:

52children (28 boys, 24 girls),age 6-22(median 14 yrs)with kidney Tx (with minimum 1 year after Tx) were recruited in the study. Causes for ESRD were: Glomerular(n=25), CAKUT(n=21), Tubulopathies(n=5) and 1 unknown.

Results:

Median age at manifestation of the disease was 5.5yrs, duration of the disease before Tx from 2 month till 17 yrs, time on dialyses before Tx from 1 month till 5.4 yrs, median age at Tx 10yrs. According to the 24 hours blood pressure (BP) monitoring only 2 patients were without AG. Creatinine level was 106.8±6.03, Urea 6.95±0.42,Glucose 5.08±0.07, total cholesterol 3.9 ± 015, high density cholesterol 1.25 ± 0.07, Low density cholesterol 0.49 ± 0.05, triglycerides 1.01 ± 0.07 and Uric acid 337.1 ± 13.67. BMI was 18. Most of the RTRs have normal ejection fraction (above 59.6%) and intima-media thickness. Left ventricular (LV) mass index was significantly higher in comparing with healthy children (p<0.05).Association between LV hypertrophy (LVH) and level of proBNP,  LVH and high-sensitive CRP was confirmed.

Conclusions:

The incidence of CV changes development in RTRs are higher than in normal populations. Appropriate routine cardiovascular screening and evaluation are needed to reduce late onset CV disease incidence.