ESPN 51th Annual Meeting

ESPN 2018


 
Comparison of Low Birth Weight Children with Healthy Normal Birth Weight Peers Considering Kidney Function and Blood Pressure
DIANA ÜÇKARDEŞ 1 AYŞE AĞBAŞ 1 BAĞDAGÜL AKSU 1 EMEL ATAOĞLU 1 DEMET OĞUZ 1 AYKUT İNSAN 2 MURAT ELEVLI 1

1- UNIVERSITY OF HEALTH SCIENCES, HASEKI EDUCATION AND RESEARCH HOSPITAL, DEPARTMENT OF PEDIATRICS, ISTANBUL
2- UNIVERSITY OF HEALTH SCIENCES, HASEKI EDUCATION AND RESEARCH HOSPITAL, DEPARTMENT OF RADIOLOGY, ISTANBUL
 
Introduction:

 Low birth weight (LBW) is a risk factor for adulthood hypertension and chronic renal injury. 

Material and methods:

In this case-control study; 24 children with LBW (<2500 gr) (mean age 7.03 ± 0.96 years), and age, gender matched 17 healthy children with normal birth weight (NBW; 2500-4000 gr) (mean age 7.54 ± 1.45 years) were included. Anthropometric measures (height SDS, weight SDS, body mass index SDS, waist to height ratio) were assessed. Serum urea, creatinine and Na, 24-hour urine Na, microalbumin and creatinine were analyzed. Casual and ambulatory blood pressure monitoring (ABPM) were performed. Kidney volume was calculated according to ellipsoid formula and indexed to body surface area. 

Results:

None of the anthropometric measures were differed except waist-height ratio (p=0.001), which was higher in LBW group. Serum creatinine was significantly higher (0.42 ± 0.06 vs 0.37 ± 0.05 mg/dl, p=0.03) and eGFR (Schwart’s formula) was significantly lower (161 ± 18.9 vs 184 ± 24.4 ml/min/1.73m2p=0.001) in LBW group. However 24-hour urine creatinine clearance was similar between two groups. Urine microalbumin and sodium excretion, and kidney volume were similar between two groups. Six patients had ambulatory hypertension; 24-h, day and night SBP and DBP-SDSs were higher, except night DBP-SDS, in LBW group. In univariate analysis day SBP-SDS was positively correlated with BMI-SDS, maternal weight at the beginning and the end of the pregnancy (p=0.02, r=0.513; p=0.01, r=0.542; p=0.03, r=0.476 respectively). In multivariate analysis maternal weight at the end of pregnancy was an independent predictor of daytime SBP-SDS (p=0.013, ß=0.374).

Conclusions:

 Maternal weight and excess weight gain of the child during catch-up growth are associated with increased systolic BP of LBW children emphasizing the importance of nutrition. Children with LBW should be followed up regularly with ABPM to early diagnose and treatment of hypertension.