ESPN 51th Annual Meeting

ESPN 2018


 
The Effects of Graft Weight on Allograft Outcomes in Children with Renal Transplant Recipients
ESRA BASKIN 1 KAAN GULLEROGLU 1 VILDAN SAHIN 1 OZLEM KAZANCI 1 BEGUM AVCI 1 EBRU AYVAZOGLU TOY 1 GOKHAN MORAY 1 MEHMET HABERAL 1

1- BASKENT UNIVERSITY
 
Introduction:

 

Renal mass has important role for a balanced graft function. Our aim is to evaluate the relation between transplanted renal mass and long term graft outcomes in renal transplant recipients.

 

Material and methods:

 Forty six children (M/F: 26/20) with kidney transplant from living related donor were enrolled to the study. Demographic data and laboratory findings were noted.Grafts (Gw) and recipients (Rw) were weighed before transplantation. Patients were divided into three groups according to the Gw/Rw ratios (Gw/Rw<3.9 (P25), Gw/Rw=3.9-9.3 (P25-P75), Gw/Rw>9.3 (P75)). Relation between Gw/Rw ration and allograft outcomes was evaluated

Results:

 

Mean age at the time of the transplantation was 14.09±4.71 years. Mean follow-up time after transplantation was 3.87±1.08 years. Mean weight of recipients and donors were 35.04±2.57 kg, 77.06±1.72 kg respectively.  Mean Gw/Rw ratio was 6.63±3.69.  At 3rd years of follow-up, mean creatinine level was 0.89±0.26 mg/dl and mean GFR value was 97.07±16.86 ml/min. A statistically significant negative correlation was demonstrated between Gw/Rw ratio and creatinine levels at 3rd months and 3rd years of follow-up (r=-7.00, p<0.01,  r=-5.86 p<0.05). Patients with Gw/Rw>9.3 had lowest mean creatinine levels during the first 6 months of transplantation when compared with patients with Gw/Rw ratio<3.9. Gw/Rw ratio was not an independent risk factor for graft survival at 3rd year of follow-up in a multivariate logistic regression analysis.

Conclusions:

 

We demonstrated a significant relation between renal mass and creatinine levels after transplantation. Higher Gw/Rw ratio can cause hyperfiltration during the first 6 months of transplantation from adult donor but it has no effect on long term outcomes.