ESPN 51th Annual Meeting

ESPN 2018


 
Effects of early post-transplant blood transfusion on graft outcome in pediatric renal transplant recipients.
OZLEM KAZANCI 1 ESRA BASKIN 1 KAAN GULLEROGLU 1 VILDAN SAHIN 1 BEGUM AVCI 1 EBRU AYVAZOGLU TOY 1 GOKHAN MORAY 1 MEHMET HABERAL 1

1- BASKENT UNIVERSITY
 
Introduction:

 

 Blood transfusion is the most frequent using procedure in correction of anemia. However early post transplant blood transfusions may increase immunological risks, antibody formation and rejection.  We aimed to evaluate effects of early post-transplant blood transfusion on graft outcome in pediatric renal transplant recipients

Material and methods:

 We retrospectively evaluated the data of 97 renal transplant patients. Demographic data , etiology of renal failure, donor types, rejections, infections, and graft outcomes were recorded. We have documented all blood transfusions given within the first one month after transplantation. All transfused blood components were leuko-depleted. Data of patients with transfused and non-transfused were compared with respect of renal outcome

Results:

 

A total of 97 patients were included study(F/M:44/52). Mean transplant age of the patients was14.43±4.76 years and the mean duration of follow-up was 48±12.76 months Twenty two patients(22.6 %) had received a blood transfusion within the first month after transplantation. Transfused patients had significantly younger than non-transfused patients (9.1±3.2, 12.7±4.5 respectively, p<0.05). The median time for first blood transfusion was 2 days (0-30 days), the median number of transfusions was 1(range:1-7) after renal transplantation. The indications of blood transfusions were acute hemorrhage, infections, and decreased Hemoglobin levels. The proportion of donor types, gender, HLA missmach and immunosuppressive treatments were similar in both groups. Also, frequency of acute and chronic rejection, graft loss, PRA formation and graft survival  were not significantly different (p>0.05)

Conclusions:

 Our study showed that early transfusions (leuco-depleted) have no negative association with increased acute and chronic rejection, PRA production and graft loss.  Further studies are needed for better evaluate the long-term risk of post-transplant blood transfusions in kidney recipients