ESPN 51th Annual Meeting

ESPN 2018


 
Evaluation of High Mobility Group Box 1 Protein as an Inflammation Marker in Patients with Familial Mediterranean Fever
BETÜL ÖZTÜRK 1 ESRA BASKIN 1 KAAN GÜLLEROĞLU 1 FERIDE ŞAHIN 1 NILÜFER BAYRAKTAR 1

1- BAŞKENT UNIVERSITY FACULTY OF MEDICINE
 
Introduction:

Recent studies reported ongoing inflammation in the attack-free period of patients with Familial Mediterranean Fever (FMF). High mobility group box protein (HMGB1) is a frequently-investigated DAMPs molecule, with a strong diagnostic and prognostic role for several chronic inflammatory diseases. We aimed to investigate HMGB1’s role in FMF. 

Material and methods:

Fifty-seven patients with FMF (27 female / 32 male) and 60 healthy children (30 female / 30 male) were included. Demographic data of patients and their parents, including the patients’ genetic analyses were recorded. Blood samples were obtained from patients and controls for HMGB1 analysis. Laboratory analysis included CRP, sedimentation, blood count, fibrinogen, creatine kinase, AST, ALT, creatinine, and microalbumin/creatinine from urine samples were recorded as well. 

Results:

 The median age was 123 months (min-max: 20-220). Thirty-three patients (57.9%) in the FMF group had a history of disease in their family, while there were consanguineous marriages in 6 of the patients’ parents (10.5%). The median follow-up of patients with FMF diagnosis was 5 years (min-max: 1-12 years). The most frequent patient mutation was M694V (78%).  Age, sex, and body weight were similar. Patients’ HMGB1 levels were significantly higher when compared to controls (p = 0.001). There was a significant positive correlation between HMGB1 and red cell distribution width (RDW), including neutrophil to lymphocyte ratio. No significant relation was observed between mutation type and HMGB1.  HMGB1 levels were similar during both the attack and the attack-free period of patients. 

Conclusions:

 This study demonstrated that HMGB1 levels in patients with FMF are significantly higher compared to healthy controls, while these levels are not influenced by the period of the disease. Further comprehensive studies, with a greater number of patients, are necessary to thoroughly examine this issue.