ESPN 51th Annual Meeting

ESPN 2018


 
SERUM GALECTIN-3 LEVELS IN PATIENTS WITH REFLUX NEPHROPATHY
SAFIYE ULKU OZCETIN 3 IBRAHIM GOKCE 1 PINAR VATANSEVER 2 HARIKA ALPAY 1

1- MARMARA UNIVERSITY MEDICAL SCHOOL DEPARTMENT OF PEDIATRIC NEPHROLOGY, ISTANBUL, TURKEY
2- MARMARA UNIVERSITY MEDICAL SCHOOL DEPARTMENT OF MEDICAL BIOCHEMISTRY, ISTANBUL, TURKEY
3- GAZIANTEP CENGIZ GOKCEK MATERNITY AND CHILDRENS HOSPITAL, GAZIANTEP, TURKEY
 
Introduction:

Reflux nephropathy(RN), still has an important place in the etiology of chronic kidney disease (CKD). Fibrosis plays a role in the pathogenesis of RN and CKD. Galectin-3(Gal-3) is considered to be a new marker for fibrosis in current studies. In the light of these information, serum Gal-3 levels in patients with renal parenchymal scarring(RPS) were examined in our study, and it was attempted to elucidate the role of serum Gal-3 levels in the diagnosis and physiopathology of RPS.

Material and methods:

Our study included 154 patients with RN between 4-18 years of age who were followed up in our outpatient clinic. Patients were divided into 3 groups according to findings on dimercaptosuccinic acid(DMSA) scintigraphy. Group 1 consisted of 19 patients with one RPS (focal scarring). Group 2 consisted of 9 patients with multiple RPS without loss of renal function. Group 3 consisted of 126 patients with renal hypodysplasia or multiple RPS and with separate renal function below 40%. Moreover, 41 age-matched healthy children without chronic disease who were admitted to our pediatric outpatient polyclinic constituted the control group (Group 4). Serum Gal-3 levels were measured in blood samples of all children.

Results:

The mean serum Gal-3 level was 10.9±13.2 ng/ml in patients with RPS and 6.9±7.7 ng/ml in healthy controls, respectively. This difference was statistically significant (p:0.010). The mean serum Gal-3 levels were also assessed separately for each scar group. There was a significant difference between Gal-3 levels and scar groups. The mean serum Gal-3 levels were increased as the degree of RPS increased (control group: 6.91±7.68, group 1: 7.73±6.90, group 2: 11.62±10.93 and group 3: 11.28±14.02 ng/ml). There was a positive linear relationship between groups.

Conclusions:

As a result, serum Gal-3 levels have been found higher in patients with RN and thought to be useful in diagnosing RPS and in elucidating its pathophysiology.