ESPN 51th Annual Meeting

ESPN 2018


 
ZINC DEFICIENCY IN CHILDREN WITH IGA VASCULITIS (HENOCH SCHONLEIN PURPURA)
FUNDA BAŞTUĞ 1 BURCU DANACI 2 HÜLYA NALÇACIOĞLU 1 SIBEL YEL 1

1- SBU KAYSERI EDUCATIONAL AND RESEARCH HOSPITAL, DEPARTMENT OF PEDIATRIC NEPHROLOGY
2- SBU KAYSERI EDUCATIONAL AND RESEARCH HOSPITAL, DEPARTMENT OF PEDIATRICS
 
Introduction:

The aim of this study is to investigate levels of serum Zinc(Zn) and oxidative stress markers during active and remission periods of children with IgA vasculitis.

Material and methods:

Fourty patients with IgA vasculitis(25 males,15 females) and 30 healthy children were included in the study. Children with IgA vasculitis were evaluated during active and remission periods(IgAV-active and IgAV-remission groups). IgAV-active group were evaluated in terms of first complaints, systemic involvement and the laboratory findings. Levels of Zn, oxidative stress markers [superoxide dismutase (SOD), glutathione peroxidase(GPx)] of IgAV-active group was compared with IgAV-remission and control groups.

Results:

 

The mean age of the patients with IgA vasculitis was 9.71 ± 6 years(1.5-16.8 years) and 62.5% of patients were male, 37.5% were female(M/F: 1.6/1).

Zinc deficiency (<60 μg / dl) was found in 20 (50%) of the IgAV-active group, 12 (30%) of the IgAV-remission group and 2 (6.6%) of the control group. Zinc deficiency was detected in statistically more significant number of the patients in the IgAV-active and IgAV-remission groups than the control group(p<0.05).

GPx levels were significantly higher in the IgA-active group than IgAV-remission and control groups(p<0.01). It was also significantly higher in the IgAV-remission group compared to the control group (p<0.05). There was no difference between the groups in terms of SOD values(p>0.05).

 

Conclusions:

To our knowledge, this is the first study to investigate the relationship between Zn and IgA vasculitis. A lot of studies have shown that Zn level is low in the inflammatory process and oxidative stress in the body. It is known that inflammation and oxidative damage play a role in the etiopathogenesis of the IgA vasculitis. In our study, it has been shown that zinc deficiency and low levels of oxidative stress marker in the active phase of patients with IgA vasculitis. This study has provided ideas for new studies on whether zinc treatments will affect the course of the disease at the active phase of the disease.