ESPN 51th Annual Meeting

ESPN 2018


 
Mean platelet volume: a useful marker in reflux nephropathy
PARSA YOUSEFICHAIJAN 1 MOHAMMAD RAFIE 3 AZIZ EGHBALI 1 MOJTABA SHARAFKHAH 2 MASOUD REZAGHOLIZAMENJANY 2 HASAN TAHERAHMADI 4 MAHDYIEH NAZIRI 2 SARA KHALIGHI 2

1- AMIR KABIR HOSPITAL, DEPARTMENT OF PEDIATRIC NEPHROLOGY, ASSOCIATE PROFESSOR OF PEDIATRIC NEPHROLOGY, ARAK UNIVERSITY OF MEDICAL SCIENCES, ARAK, IRAN.
2- SCHOOL OF MEDICINE, ARAK UNIVERSITY OF MEDICAL SCIENCES, ARAK, IRAN.
3- DEPARTMENT OF BIOSTATISTICS, ARAK UNIVERSITY OF MEDICAL SCIENCES, ARAK, IRAN.
4- DEPARTMENT OF PEDIATRIC, ASSOCIATE PROFESSOR OF PEDIATRIC, ARAK UNIVERSITY OF MEDICAL SCIENCES, ARAK, IRAN.
 
Introduction:

The inflammatory reaction caused by a pyelonephritis infection can result in renal injury or scarring, which is also termed reflux-related renal injury or reflux nephropathy. The importance of platelet changes is emphasized in some chronic diseases. In this study, the changes of mean platelet volume (MPV) and mean platelet count (MPC) were investigated in children with reflux nephropathy.

Material and methods:

In this case-control study, 107 females with vesicoureteral reflux (VUR) (grade 1 to 3) and reflux nephropathy and 107 females with VUR (grade 1 to 3) without reflux nephropathy were included. Demographics characteristics of the patients were recorded and laboratory parameters in the active phases of first pyelonephritis were evaluated.

Results:

MPC was higher in patients with reflux nephropathy than non-reflux nephropathy patients and MPV was lower in the patients with reflux nephropathy than patients without reflux nephropathy.


Conclusions:

MPV can be used as an indicator in diagnosis of reflux nephropathy in patients with VUR.