ESPN 51th Annual Meeting

ESPN 2018


 
IS THERE A POSSIBILITY TO PREVENT PROGRESSION OF OBESITY RELATED CHRONIC KIDNEY DIASEASE; MICROALBUMINURIA
EBRU YILMAZ 1 NIDA TEMIZKAN DINCEL 1 CEMALIYE BASARAN 1 GULCIN ARSLAN 2 FATMA DEVRIM 1 SERKAN KEMER 1 ORHAN DENIZ KARA 1 OZLEM NALBANTOGLU 2 BEHZAT OZKAN 2 ERKIN SERDAROGLU 1

1- UNIVERSITY OF HEALTH SCIENCES DR. BEHCET UZ CHILDRENS HOSPITAL DEPARTMENT OF PEDIATRIC NEPHROLOGY
2- UNIVERSITY OF HEALTH SCIENCES DR. BEHCET UZ CHILDRENS HOSPITAL DEPARTMENT OF PEDIATRIC ENDOCRINOLOGY
 
Introduction:

Lower urinary tract dysfunction (LUTD) is associated with anatomical, functional or neurological disorders of bladder filling or emptying phases. However a new causative heading is the obesity. Obesity alters bladder wall functional histology due to inflammatory response related with insulin resistance or leads to dysfunctional voiding via prevention of complete bladder emptying. The aim of this study is to examine the emptying phase of bladder and to evaluate the relation between uroflow parameters and insulin resistance.

Material and methods:

Totally 154 obese children were included the study. Subjects with type 1 diabetes, previous kidney diseases, any other chronic disease or genetic syndromes were excluded. Analyses were performed to assess the relationship between voiding pattern, maximum velocity of urine flow (Q max), average velocity of urine flow (Qave), time to reach to Qmax, and voided volume and metabolic parameters, such as body mass index (BMI), BMI SDS, homeostatic model assessment for insulin resistance (HOMA-IR).

Results:

The patients were classified into 2 groups; insulin resistant group (group 1, n=85), no-insulin resistant (group 2, n=69). The mean age of patients was 11.9 ±3.4 and 11.8± 3.2 years (group 1 and 2, respectively). The incidence of microalbuminuria in total was 8.4% (9.4% in group 1 and 7.2% in group 2, p>0.05) which unignorable higher percentage in both groups whether IR presence or not. There were no correlation between BMI, BMI SDS, metabolic syndrome criteria and MA. Neither the metabolic syndrome nor any of the demographic factors examined were associated with MA.

Conclusions:

These are the preliminary results of our ongoing study. MA which is a strong early biomarker of CKD. We recommend the inclusion of microalbuminuria in routine screenings of pediatric obese patients.