ESPN 51th Annual Meeting

ESPN 2018


 
LOWER URINARY TRACT DYSFUNCTION AND INSULIN RESISTANCE. IS THERE A REALLY CORRELATION BETWEEN THEM?
NIDA TEMIZKAN DINCEL 1 EBRU YILMAZ 1 FATMA DEVRIM 1 CEMALIYE BASARAN 1 SERKAN KEMER 1 ORHAN DENIZ KARA 1 OZLEM NALBANTOGLU 2 GULCIN ARSLAN 2 KIYMET KARAGOZ 3 ERKIN SERDAROGLU 1 BEHZAT OZKAN 2

1- UNIVERSITY OF HEALTH SCIENCES DR. BEHCET UZ CHILDRENS HOSPITAL DEPARTMENT OF PEDIATRIC NEPHROLOGY
2- UNIVERSITY OF HEALTH SCIENCES DR. BEHCET UZ CHILDRENS HOSPITAL DEPARTMENT OF PEDIATRIC ENDOCRINOLOGY
3- UNIVERSITY OF HEALTH SCIENCES DR. BEHCET UZ CHILDRENS HOSPITAL
 
Introduction:

Lower urinary tract dysfunction (LUTD) is associated with anatomical, functional or neurological disorders of bladder filling or emptying phases. However a new causative heading is the obesity. Obesity alters bladder wall functional histology due to inflammatory response related with insulin resistance or leads to dysfunctional voiding via prevention of complete bladder emptying. The aim of this study is to examine the emptying phase of bladder and to evaluate the relation between uroflow parameters and insulin resistance.

Material and methods:

Totally 154 obese children were included the study. The cases with type 1 diabetes, previous kidney diseases, known bladder dysfunction, any other chronic disease or genetic syndromes were excluded. All patients performed uroflowmetric exam. Analyses were performed to assess the relationship between voiding pattern, maximum velocity of urine flow (Q max), average velocity of urine flow (Q aver), time to reach to Qmax, and voided volume and metabolic parameters, such as body mass index (BMI), BMI SDS, homeostatic model assessment for insulin resistance (HOMA-IR).

Results:

The patients were classified into 2 groups; insulin resistant group (group 1, n=85), no-insulin resistant (group 2, n=69). The mean age of patients was 11.9 ±3.4 and 11.8± 3.2 years (group 1 and 2, respectively). There weren’t correlation between BMI, BMI SDS, metabolic syndrome criteria and uroflow parameters. Neither the metabolic syndrome nor any of the demographic factors examined were associated with uroflow parameters except for Q aver. Median Qaver was 12.5 second (IQR: 4.7-19.2) in group 1 and 18.5 second (IQR: 14.5-23.0) in group 2; p=0.031

Conclusions:

The preliminary results of our ongoing study showed that IR had affect on the Q aver. thus it was a risk factor for LUTD