ESPN 51th Annual Meeting

ESPN 2018


 
LONG-TERM RESULTS OF PREEMPTIVE KIDNEY TRANSPLANTATION
GÜLŞAH KAYA 1 MUSTAFA KOYUN 1 ELIF ÇOMAK 1 SEMA AKMAN 1

1- AKDENIZ UNIVERSITY, MEDICAL FACULTY, DEPARTMENT OF PEDIATRICS, DIVISION OF PEDIATRIC NEPHROLOGY, ANTALYA, TURKEY
 
Introduction:

It was reported that preemptive kidney transplantation (PKT) had improved graft and patient survival. In this study, we aimed to investigate the long-term results of PKT.

Material and methods:

In this retrospective study, we examined the records of patients who underwent kidney transplantation between 2005-2017 with a minimum 1 year of follow-up. Glomerular filtration rate (GFR), graft failure and mortality rates receiving preemptive versus non-preemptive kidney transplants were compared. 

Results:

230 pediatric renal tx recipients were included in the study. The majority of recipients were male (60.9%) and received a living donor (70.8%). The most common causes of ESRD were CAKUT (42.2%). 45.7% of the patients underwent PKT. Mean age at transplantation and mean follow-up period were similar between PKT and non-PKT recipients (10.79±5.03 vs 11.45±4.65 years, p=0.23 and 4.71±2.61 vs 5.88±9.38 years, respectively, p=0.64). Within a median 7.23 years of follow-up period, a total of 24 recipients (10.4%) experienced graft failure and 7 patients (3.0%) died. Risk of graft failure and mortality were similar between PKT and non-PKT recipients (7.54% vs 12.9%, HR: 1.30; 95% CI: 0.54-3.12 and 2.83% vs 3.22%, HR: 1.02; 95%CI: 0.22-4.60). Mean GFR at the time of study was similar between PKT and non-PKT recipients (76.91±24.47 vs 87.66±62.7 ml/min/1.73 m2, respectively, p=011). 

Conclusions:

 We found that preemptive kidney transplantation was not superior to tx after renal replacement therapy in terms of graft and patient survival.