ESPN 51th Annual Meeting

ESPN 2018


 
Eicosapentanenoic acid and blood pressure in pediatric renal transplant recipients
HJORDIS THORSTEINSDOTTIR 1 IVAR ANDREAS EIDE 3 My Svensson 1 Anine Lie 1 Andreas Aasberg 2 ANNA BJERRE 1

1- DIVISION OF PAEDIATRIC AND ADOLESCENT MEDICINE, OSLO UNIVERSITY HOSPITAL
2- Department of Transplantation Medicine, Oslo University Hospital
3- Department of Renal Medicine, Akershus University Hospital
4- Institute of Clinical Medicine, University of Oslo
 
Introduction:

The major marine n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may improve cardiovascular health in renal transplant recipients (RTRs). The aim of this study was to evaluate the relationship between plasma marine n-3 PUFA levels and cardiovascular risk factors in pediatric RTRs

Material and methods:

This cross-sectional study included 47 Norwegian pediatric RTRs (aged 2.3 to 15.6 years, 29 males). Associations between plasma EPA and DHA levels and cardiovascular risk factors were evaluated by univariate and multivariable adjusted linear regression.

Results:

RTRs without hypertension had significantly higher levels of EPA (p = 0.045) but not of DHA. HDL was negatively correlated to EPA (r = -0.32, p = 0.032). After adjustment for traditional cardiovascular risk factors (BMI SDS-score, cholesterol, triglycerides), recipient age and time since transplantation, hypertension was the only significant predictor of EPA (p = 0.014). Plasma DHA level was not associated with cardiovascular risk factors.

Conclusions:

Higher plasma levels of EPA were negatively associated with hypertension in pediatric RTRs. So far little data have been published on the effects of n-3 PUFA levels in pediatric organ transplant recipients. In other populations, including adult RTRs, there is a well-established relationship between plasma n-3 PUFA levels and triglyceride levels and why this differ in our pediatric population remains unanswered and is a possible area for future research.