ESPN 51th Annual Meeting

ESPN 2018


 
Thiol/Disulphide Homeostasis in Children With Chronic Kidney Disease
FATMA YAZILITAŞ 1 FATMA ZEHRA ÖZTEK-ÇELEBI 1 FEHIME KARA EROĞLU 1 EVRIM KARGIN ÇAKICI 1 GÖKÇE GÜR 1 MEHMET BÜLBÜL 1 MURAT ALIŞIK 2 ÖZCAN EREL 2

1- DR SAMI ULUS MATERNITY AND CHILD HEALTH AND DISEASES TRAINING AND RESEARCH HOSPITAL
2- YILDIRIM BEYAZIT UNIVERSITY
 
Introduction:

 The plasma thiols are formed mainly by albumin thiols. Thiols play an important role in protective mechanisms against oxidative stres. We aimed to to determine blood dynamic thiol/disulphide homeostasis as markers of oxidative stress in childhood in chronic kidney disease (CKD). 

Material and methods:

 The age and sex matched children who 50 patients with CKD and with 50 healthy volunteers were included in this prospective study. The thiol/disulphide homeostasis (native thiol, total thiol, and disulphide levels and also native thiol/total thiol ratios, disulphide/native thiol, and disulphide/total thiol ratios) were investigated with a newly developed both automated and colorimetric method improved by Erel and Neşelioğlu in 2014.

Results:

 The study participants consisted of a total of 100 children, including 50 CKD patients (mean age of 11,8 ± 5,2; median 12 years; range 0-18) and 50 controls (mean age of 11,1 ± 4,4years:  median 12 years; range 1-18 years). In patients with chronic kidney disease compared to the control group, there was a statistically significant reduce with associated a decrease in albumin levels in the levels of native thiols, total thiols and disulphides. 

Conclusions:

 This is the first study investigating the thiol/disulphide homeostasis with a new automated analyzer in pediatric chronic kidney disease. We demonstrated that the dynamic thiol/disulphide balance was not affected in patients with CKD.