ESPN 51th Annual Meeting

ESPN 2018


 
The Effect of Erythrocyte Stimulating Agents on Platelet/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio
FATMA YAZILITAŞ 1 EVRA ÇELIKKAYA 1 FEHIME KARA EROĞLU 1 GÖKÇE GÜR CAN 1 EVRIM KARGIN ÇAKICI 1 TÜLIN GÜNGÖR 1 MEHMET BÜLBÜL 1

1- DR SAMI ULUS MATERNITY AND CHILD HEALTH AND DISEASES TRAINING AND RESEARCH HOSPITAL
 
Introduction:

 Chronic renal disease (CKD) is associated with some hematologic changes such as decreased platelet production, platelet dysfunction and thrombocytosis. The inflammatory markers increase in CKD. Mean platelet volume (MPV), the ratio of neutrophil count to lymphocyte count (NLR), and the ratio of platelet count to lymphocyte count (TLR) are indicative of inflammation. Erythrocyte stimulating agents (ESA) can increase platelet count and thrombotic events. We aimed to determine the relationship between the use of ESA and MPV, NLR and TLR in children with CKD in this study.

Material and methods:

 The files of 30 patients diagnosed with CKD and treated with ESA between 2013 and 2018 were reviewed retrospectively.

Results:

 The mean age of the patients (16 boys and 14 girls) was 10.6 ± 5.4 years (median 12; 1-17 years). Twelve of them were in pre-dialysis, 9 in hemodialysis (HD) and 9 in peritoneal dialysis (PD) group. The mean ESA duration of the patients was 29.2 ± 34.8 months (median 12.5; 1-127 months). The MPV values after treatment with ESA in CKD patients were significantly higher in all groups. TLR values after treatment with ESA were not significant different in all groups. TLR had a significant but opposite correlation with MPV, white cell count and monocyte counts. MPV and NLR measurements were affected by dialysis modality. However TLR was not affected.

Conclusions:

 In this small retrospective study, we could not report causality and effect associations in our results. Nevertheless, these simple, cheap, universal methods may be used as the first step in the evaluation of patients by nephrologists.