ESPN 51th Annual Meeting

ESPN 2018


 
URINE PENTRAXIN 3 LEVELS AS A MARKER FOR THE PRESENCE OF RENAL PARENCHYMAL SCAR
TÜLAY BECERIR 1 SELÇUK YÜKSEL 2 HAVVA EVRENGÜL 3 AHMET ERGIN 4 YAŞAR ENLI 5

1- DEPARTMENT OF PEDIATRIC NEPHROLOGY, NAMIK KEMAL UNIVERSITY SCHOOL OF MEDICINE
2- DEPARTMENT OF PEDIATRIC RHEUMATOLOGY AND NEPHROLOGY, PAMUKKALE UNIVERSITY
3- DEPARTMENT OF PEDIATRIC NEPHROLOGY, PAMUKKALE UNIVERSITY SCHOOL OF MEDICINE
4- DEPARTMENT OF SOCIAL PEDIATRICS, PAMUKKALE UNIVERSITY SCHOOL OF MEDICINE
5- DEPARTMENT OF BIOCHEMISTRY, PAMUKKALE UNIVERSITY SCHOOL OF MEDICINE
 
Introduction:

In this study, we suggested that the levels of uPTX3 might be used as a non-invasive marker to determine the presence RPS. We showed that the urinary PTX3 was only increased in patients with scarred kidney. This result may be indicative of ongoing inflammation and may be helpful in identifying the scar. 

Material and methods:

The study consisted of 88 children (31 male, 57 female) aged between 3 months and 18 years. The children included in the study were divided into 4 groups: Group 1; VUR with RPS (8 male, 18 female); Group 2; RPS without VUR (9 female, 9 male); Group 3; VUR without RPS ( 2 male, 11 female); and Group 4; healthy children without hydronephrosis and UTI history (12 male, 24 female). After the first evaluation, children were divided into 2 more different groups and re-evaluated for comparison purposes: Children with RPS (Group 1+2), children without RPS (group 3+4), children with VUR (group 1+3), and children without VUR (group 2+4).

Results:

We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS (uPTX3; 3.5 pg/mg vs 2.2pg/mg and uPTX3/creatinine; 10.5 pg/mg vs 5.8 pg/mg, p=0.006 respectively). uPTX3 levels were not different among the groups with and without VUR. In addition serum PTX3 levels were not different among the groups

Conclusions:

In this study, we suggested that the levels of uPTX3 might be used as a non-invasive marker to determine the presence RPS. We showed that the urinary PTX3 was only increased in patients with scarred kidney. This result may be indicative of ongoing inflammation and may be helpful in identifying the scar.