ESPN 51th Annual Meeting

ESPN 2018


 
RESIDUAL RENAL FUNCTION IN CHILDREN WITH CONTINIOUS AMBULATORY PERITONEAL DIALYSIS
GULTEN ERCAN 1 ERKIN SERDAROGLU 1 SUKRAN KESKIN GOZMEN 1

1- UNIVERSITY OF HEALTH SCIENCES DR. BEHCET UZ CHILDREN’S HOSPITAL DEPARTMENT OF PEDIATRIC NEPHROLOGY
 
Introduction:

Residual renal function (RRF) is one of the most important factor effecting quality of life, morbidity and mortality in patients treated with continuous ambulatory peritoneal dialysis (CAPD). The aim of this study was to evaluate RRF, effecting factors and results in children on CAPD.

Material and methods:

Fifty patients (26 girls) receiving PD who were followed up at least 6 months on CAPD were included the study. All patients followed minimum 36 months in standard care and evaluated every 6 months for study parameters.

Results:

The mean age was 120±57 months. At starting to CAPD, RRF was found 874±660 ml/m2 and creatinine clearance was found 3.3±3.0 ml/dk/1.73m2. RRF was 640±556 at one year, 497±537 at second year and 510±574 ml/m2 at third year. Mean decrease of urine volume was -10±19 ml/m2/mo. Fourteen (28%) patients became anuric at follow up (mean time 16±5 months). Primary glomerular disease (%54, p=0.02), low urine volume on start (576±418 vs. 989±704 ml/m2, p=0.01), high proteinuria (78±82 vs. 34±26 mg/m2/hr, p<0.01), low serum albumin (2.6±0.6 vs. 3.4±0.5 g/dl, p<0.01) was related with anuria. Decreasing in RRF was found higher ACEIs using patients than others (-21±15 vs. -4±19 ml/m2/mo, p=0.05). RRF decreasing rate (ml/m2/mo) was positively correlated with mean Hb (r=0.69), Kt/V (r=0.70), total creatinine clearance (r=0.54) and was negatively correlated with urine volume on start (r=-0.61), ambulatory 24hr MAP (r=-0.59). Dialysis modality, peritoneal permeability, ultra filtration rate, peritonitis, left ventricular mass index was not found related with RRF.

Conclusions:

 RRF as a major factor for morbidity and mortality was related with primary disease, urine volume on start, drugs and some treatment parameters.