ESPN 51th Annual Meeting

ESPN 2018


 
Patient outcomes of Henoch Schönlein Purpura nephritis according to the new semiquantitative classification in a single center
SIBEL YEL 1 İSMAIL DURSUN 1 AYŞE SEDA PINARBAŞI 1 NESLIHAN GÜNAY 1 SÜMEYRA ÖZDEMIR 1 NIHAL ŞAHIN 1 HÜLYA AKGÜN 2 FUNDA İPEKTEN 3 M. HAKAN POYRAZOĞLU 1 RUHAN DÜŞÜNSEL 1

1- DEPARTMENT OF PEDIATRIC NEPHROLOGY AND RHEUMATOLOGY, ERCIYES UNIVERSITY FACULTY OF MEDICINE, KAYSERI, TURKEY
2- DEPARTMENT OF PATHOLOGY, ERCIYES UNIVERSITY FACULTY OF MEDICINE, KAYSERI, TURKEY
3- DEPARTMENT OF BIOSTATISTICS, ERCIYES UNIVERSITY FACULTY OF MEDICINE, KAYSERI, TURKEY
 
Introduction:

 A new modified semiquantitative classification (SQC) that takes into account the activity, chronicity and tubulointerstitial indices for pediatric Henoch–Schönlein nephritis (HSN) was defined recently. Histological findings of kidney biopsies with HSN patients and their outcomes are evaluated according to the new classification in a single center.

Material and methods:

 Primary kidney biopsies from 80 HSN patients were re-evaluated using the new modified SQC. The International Study of Kidney Disease in Children (ISKDC) and SQC classifications were compared in terms of the patient outcomes. Outcomes were defined as follow; Outcome A (n=44) patients with no sign of renal disease,  Outcome B (n=32) patients with minor urinary abnormalities, Outcome C (n=4) patients with active renal disease. Renal insufficiency or end-stage renal disease was not detected in any patient. The median follow-up time was 3 years. For the receiver operating characteristic analysis groups B+C were combined. 

Results:

 The patients with outcome C had significantly higher total biopsy SQC scores and chronicity indices than patients in group A. The activity indices were not differed between groups. There was no significant difference in areas under the curve between total biopsy SQC scores and ISKDC findings.

Conclusions:

 Our results suggest that the modified SQC is as sensitive as ISKDC classification for predicting the outcome in HSN cases.