ESPN 51th Annual Meeting

ESPN 2018


 
Nephrotic Syndrome in the first year of life: case series of 28 Infants
GURDEEP SINGH DHOORIA 1

1- DAYANAND MEDICAL COLLEGE AND HOSPITAL, LUDHIANA, PUJAB, INDIA
 
Introduction:

 Nephrotic syndrome (NS) with onset within 1st year has a varied etiology and  prognosis. Aim: To study clinical spectrum, histopathological findings and  outcome of infantile NS. Design: Retrospective observational study.     

Material and methods:

 Twenty eight infants with NS with onset within one year of life (Infantile NS) were subclassified as Congenital NS ( 3 cases) and Infantile NS (25 cases). Case records were reviewed for clinical features, investigations including TORCH infections, clinical course and complications. Renal Biopsy  was done were indicated.

Results:

 

Fifty seven percent of cases were between 9-12 months of age. Male: female ratio was 1.33:1. Associated abnormalities were seen in  9 cases (32%). Cases of congenital nephrotic syndrome had overall poorer outcome with only one of  3 cases survived, having normal renal function at last follow-up. Of the 25 cases of infantile nephrotic syndrome, 19 cases had normal renal function at last follow-up, 4 cases progressed to chronic kidney disease and 2 cases were lost to follow-up.

Renal biopsy was done in 14 of  25 cases of infantile NS. Most common histopathological finding  seen was Minimal change Nephrotic syndrome (MCNS)(6) followed by Focal segmental glomerular sclerosis (FSGS) (4), congenital nephrotic syndrome Finnish variety (2) and Diffuse Mesangeal sclerosis (1).

Conclusions:

 

“Finnish variety” was common in congenital NS and  MCNS was found to be the most common histopathological finding in the Infantile variety of nephrotic syndrome. Associated anomalies are frequently associated. Significant number (52%) of cases responded to Steroids.