ESPN 51th Annual Meeting

ESPN 2018


 
Evaluation of Maternal History for Congenital Anomalies of Kidney and Urinary Tract
ELİF YILDIRIM 1 ZEYNEP NAGEHAN YÜRÜK YILDIRIM 2 ÖZDE NİSA TÜRKKAN 2 EMİNE ÖZLEM ÇAM DELEBE 2 ALEV YILMAZ 2 AHMET NEVZAT NAYIR 2

1- ISTANBUL UNIVERSITY, ISTANBUL FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRICS, ISTANBUL, TURKEY
2- ISTANBUL UNIVERSITY, ISTANBUL FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRIC NEPHROLOGY, ISTANBUL, TURKEY
 
Introduction:

Congenital anomalies of kidney and urinary tract (CAKUT) is a spectrum of renal, ureteral, bladder and urethral anomalies. We aimed to characterize subgroups of CAKUT and possible maternal risk factors for CAKUT. 

Material and methods:

One hundred patients attended to pediatric nephrology outpatient clinic diagnosed as CAKUT were enrolled in the study. The patient’s files were reviewed retrospectively, patients and their family invited to outpatient clinic. Maternal history information was reevaluated by a questionnaire. Patients were divided into 2groups as upper and lower CAKUT. These two groups were compared in respect of antenatal drug use, smoking, diabetes mellitus/hyperglycemia, hypertension, vegetarian diet and maternal weight gain.

Results:

Antenatal follow-up by a gynecologist had been performed regularly in only 50%. Antenatal diagnosis was made 51.2% in upper  and 59,4% in lower CAKUT. Multicystic dysplastic kidney and renal agenesis were found as the most common anomalies in upper CAKUT and posterior urethral valve and vesicoureteral reflux in lower CAKUT group. Maternal history revealed the frequencies of risk factors as cigarette smoking 13%, prescriptional drug use 8%, diabetes mellitus 23.5%, hypertension 35.3%, hyperglycemia 41.2% and vegetarian diet 11.8%. Only 17% of the cases had preterm birth history. Maternal multivitamin use was 74% in cases. Maternal weight gain was >20 kg in 19% of the patients.In comparison of upper and lower CAKUT, there were no differences according to maternal risk factors except that maternal weight gain was higher in upper than the lower CAKUT (p˂ 0.05) whereas maternal drug use was higher in lower CAKUT than the upper (p˂ 0.05).

Conclusions:

Determination of maternal risk factors of CAKUT will increase the awareness for diagnosis of CAKUT for physicians especially in the patients without antenatal diagnosis of CAKUT.