ESPN 51th Annual Meeting

ESPN 2018


 
Evaluation of Atrial and Ventricular Repolarization in Children with Renal Transplantation
BELDE KASAP DEMIR 2 EREN SOYALTIN 1 CANER ALPARSLAN 1 SEÇİL ARSLANSOYU ÇAMLAR 1 TÜLAY DEMİRCAN 4 CEM KARADENİZ 3 ÖNDER YAVAŞCAN 1 FATMA MUTLUBAŞ 1 DEMET ALAYGUT 1

1- IZMIR TEPECIK TRAINING AND RESEARCH HOSPITAL DEPARTMENT OF PEDIATRICS DIVISION OF NEPHROLOGY, IZMIR, TURKEY
2- IZMIR KATIP ÇELEBI UNIVERSITY DEPARTMENT OF PEDIATRICS DIVISION OF NEPHROLOGY, IZMIR, TURKEY
3- IZMIR KATIP ÇELEBI UNIVERSITY DEPARTMENT OF PEDIATRICS DIVISION OF CARDIOLOGY, IZMIR, TURKEY
4- Izmir Tepecik Training and Research Hospital Department of Pediatrics Division of Cardiology, Izmir, TURKEY
 
Introduction:

P-wave dispersion (PWd) and QT dispersion (QTd) represent the heterogeneity of atrial depolarization and ventricular repolarization, respectively. Aside from QT dispersion, new parameters derived from 12-lead surface ECG, such as the Tp-e interval, which is the measurement of the interval between the peak and the end of the T wave, Tp-e /QT, Tp-e/QTc. These parameters have been found to be highly useful in predicting atrial and ventricular arrhythmias. We aimed to investigate these parameters in renal transplant (RTx) patients.

Material and methods:

The children and adolescents who underwent RTx between March 2005 and October 2017 in Izmir Tepecik Research Hospital were evaluated prospectively. Thirty-one RTx patients and age and sex- matched 33 healthy controls were included. Patients with diabetes mellitus, heart failure and eGFR<60ml/min/1.73m2 were excluded. All participants were evaluated with 12-lead surface electrocardiography and echocardiographic examination. All ECG parameters were measured with computer based software programme.  

Results:

The RTx period of the patients were determined to show variation from 9 to 163 months. The patient’s mean eGFR was 102,5±31,3. Both groups were smiliar in terms of age and sex.  Patients tended to have higher diastolic blood pressure (p: 0,000). RTx patients had significantly higher left ventricular mass index (P: 0,005), compared with controls. A statistically significiant difference was observed in the mean PWd (p:0,016), QTd (p: 0,005), QTcd (p: 0,000), Tp-e min/QTmin (p:0,007), Tp-e min/QTcmin (p:0,000), Tp-emax/QTcmax (p:0,048) among two groups.

Conclusions:

Children and adolescents with renal tx, may be considered at some risk of developing arrhythmias despite appraised renal functions. Therefore, careful evaluation of these ECG parameters is necessary  Further, prospective electrophysiological studies using 24-h ECG monitoring are needed to exhibit the clinical usefulness and prognostic implications of these parameters.