ESPN 51th Annual Meeting

ESPN 2018


 
Evaluation of Platelet Indices as Novel Markers for Nephrotic Syndrome
SERRA SÜRMELI DÖVEN 1 HARIKA KAYACAN 1 SEMRA ERDOĞAN 1 BANU İNCE 2 ALI DELIBAŞ 1

1- MERSIN UNIVERSITY FACULTY OF MEDICINE
2- ADANA CITY HOSPITAL
 
Introduction:

 Platelets play an important role in the pathogenesis of nephrotic syndrome (NS). The aim of this study was to evaluate platelet indices as markers for this disorder. 

Material and methods:

 A total of 39 patients (26 males, 13 females) with NS followed-up by the pediatric nephrology department in our center from January 2017 to January 2018 were enrolled in the study. Participants were divided into two groups, those with steroid-sensitive nephrotic syndrome (SSNS) (n = 23) and those with steroid-resistant nephrotic syndrome (SRNS) (n = 13). Laboratory parameters, including neutrophils, lymphocytes, white blood cells, platelet counts, mean platelet volume, platelet distribution width, plateletcrit, and platelet large cell ratio were reviewed retrospectively. Similar parameters from a control group consisting of 30 age- and sex-matched healthy subjects were also evaluated and compared to the study groups.

Results:

 White blood cells, neutrophil count, platelet, and plateletcrit values were greater in NS patients when compared to controls. When evaluated based upon steroid resistance status, no statistical difference was observed between the SSNS group and controls in terms of platelet indices; however, plateletcrit values were greater in the SRNS group compared to the control group (P = 0.007).

Conclusions:

 Plateletcrit could be useful as a marker of inflammation for SRNS. More studies with large sample sizes should be performed to determine changes in platelet indices that occur in association with NS.