ESPN 51th Annual Meeting

ESPN 2018


 
CAN WE USE COPEPTIN AS A BIOMARKER FOR MASKED HYPERTENSION IN OBESE CHILDREN AND ADOLESCENTS?
DUYGU ERTAN 5 BELDE KASAP DEMIR 1 CANER ALPARSLAN 2 HURIYE ERBAK 4 GÖNÜL ÇATLI 3 FATMA MUTLUBAŞ 2 DEMET ALAYGUT 2 EREN SOYALTIN 2 SEÇIL ARSLANSOYU ÇAMLAR 2 ÖNDER YAVAŞCAN 2

1- IZMIR KATIP ÇELEBI UNIVERSITY DEPARTMENT OF PEDIATRICS DIVISION OF NEPHROLOGY, IZMIR, TURKEY
2- IZMIR TEPECIK TRAINING AND RESEARCH HOSPITAL DEPARTMENT OF PEDIATRICS DIVISION OF NEPHROLOGY, IZMIR, TURKEY
3- IZMIR KATIP ÇELEBI UNIVERSITY DEPARTMENT OF PEDIATRICS DIVISION OF ENDOCRINOLOGY, IZMIR, TURKEY
4- IZMIR ATATÜRK RESEARCH AND TRAINING HOSPITAL DEPARTMENT OF MEDICAL BIOCHEMISTRY, IZMIR, TURKEY
5- IZMIR TEPECIK TRAINING AND RESEARCH HOSPITAL DEPARTMENT OF PEDIATRICS IZMIR, TURKEY
 
Introduction:

Copeptin is the C-terminal part of arginine-vasopressin (AVP) and can be measured easily in serum. Serum copeptin levels were found higher in hypertensive adolescents and there is a close association between metabolic syndrome (MS) and AVP. We aimed to investigate the use of serum copeptin as a biomarker in obese cases with masked hypertension (MHT). As a secondary aim, we investigated whether copeptin might indicate patients with MS.

Material and methods:

Our study included normotensive children aged 10-18 years diagnosed with obesity (BMI:SDS>2) between October 2015-April 2017. Biochemical tests, copeptin, BNP, aldosterone and renin levels, urine samples were collected. Echocardiographic, fundoscopic examinations and ambulatory blood pressure monitoring (ABPM) were assessed. Patients were grouped as MHT and NT, and MS and non-MS. Parameters were compared between the groups.

Results:

The rate of MHT was 52.5% and the rate of metabolic syndrome was 23.75%. Waist (p:0.001), arm (p:0,004) and hip (0.002) circumferences; familial HT history (0.017); SVH (p:000) and HTRP (p:0.027) frequencies; serum creatinine (p:0.046), uric acid (p:0.038) levels were significantly higher in MHT group. TG (p:0.000) and uric acid (p:0.038) levels were significantly higher in patients with MS. Urinary Na excretion, copeptin, renin, aldosterone, and BNP levels were similar between the groups of MHT vs. non-MHT, and MS vs. non-MS groups. Copeptin levels were significantly correlated with aldosteron and BNP levels in the whole group.  When splitted for MHT or MS, no significant correlation of copeptin with any specific parameter could be demonstrated.   

Conclusions:

Copeptin is not a marker for MHT or MS in obese children. In addition, sodium intake or renin-aldosteron activation was not seem to be the underlying cause of MHT in this group of patients.