ESPN 51th Annual Meeting

ESPN 2018


 
The Relationship Between the Prevalence of Masked Hypertension and Vitamin D in Patients with Renal Scarring
MERVE OCALAN 1 IPEK AKIL 1

1- MANISA CELAL BAYAR UNIVERSITY
 
Introduction:

 The aim of this study is to determine the prevalence of masked hypertension in patients with renal scars and to investigate the relationship between vitamin D metabolism and VDR gene polymorphism.

Material and methods:

 In this cross-sectional prospective study, 40 children were evaluated as patient group between the ages of 8-18 years who were admitted to the Pediatric Nephrology Clinic of Manisa Celal Bayar University Medical Faculty Hospital between 2015 and 2017. 38 healthy children were included in the study as control group. All children were monitored for blood pressure with a 24-hour ambulatory blood pressure monitor (ABPM) and a clinical blood pressure measurement at least four times on two different days. Carotid artery intima media thickness (cIMT), an early vascular indicator of target organ damage in hypertension, was measured by carotid doppler ultrasonography in each case. Serum 25 hydroxy vitamin D levels and fok-1 D vitamin receptor gene polymorphism were studied. The glomerular filtration rate was calculated in 24 hour urine.

Results:

 The prevalence of masked hypertension was 5% in the patient group. No significant difference was found between serum vitamin D levels in the patient and control group. When the renal scar severity was increased in the patient group, the serum vitamin D level decreased (p = 0.03). When VDR gene polymorphism, proteinuria and GFR levels were examined, no difference was found between the patients and controls, no difference was found between hypertensive and normotansive children.

Conclusions:

 If the relationship between renal scarring severity and D vitamine deficiency is confirmed in more comprehensive studies, D vitamin supplementation may occur in the treatment of patients with renal scars.