ESPN 51th Annual Meeting

ESPN 2018


 
Association between renal size, renal function, microalbuminuria and perinatal variables in a population of children born preterm
LUIS IGNACIO RODRIGUEZ 1 MARIA EMILIA CARAM 2 MARíA ZAIRA PEREZ 2 MARIANA MAURISSI 3 MARCELA DURSO 4 SUSANA MICELI 1

1- CHILD AND ADOLESCENT MEDICINE DEPARTMENT. FACUTAD DE MEDICINA OF TUCUMáN-ARGENTINA
2- PRETERM NEWBORN MONITORING OFFICE, HOSPITAL DE NIñO JESúS DE TUCUMáN
3- ULTRASOUND SERVICE OF HOSPITAL DE NIñO JESúS OF TUCUMáN
4- BIOSTATISTICS DEPARTMENT, FACULTAD DE MEDICINA DE TUCUMáN-ARGENTINA
 
Introduction:

Clinical and laboratory measures of glomerular function are necessary for an accurate and efficient assessment of renal function in preterm infants. Goals: Study in children born premature (CBP), kidney size and risk markers of renal function, glomerular filtration rate (GFR), urinary micro albuminuria (UMA) and blood pressure (BP). Associate renal size with some perinatal characteristics and renal risk markers.

Material and methods:

Cross-sectional descriptive study. The variables were sex, GE grouped in ≤ 30 s, and ≥ 30 s, birth weight (BW) in grams (g), grouped in ≥ to 1000, <of 1000. At the time of control, weight (W), Size (S) and BP classified according Task Force. Laboratory: creatinine (Cr) mg/dl and urinary ratio UMA/Cr (mg/g). The Cr was stratified: 0.1-0.3; > 0.3-0.6 and> 0.6. GFR by Schwarts formula (ml / min): Normal (90 -120), low (<90) and hyperfiltered (> 120). Kidney diameters were measured by ultrasound: length (L), posterior anter (PA), transverse (T) and relative L (LR), volume absolute (VA), relative (VR) and predictive (VP) were calculated to evaluate size right renal (RD) and left (RI). We used ultrasound, TOSHIBA model NEMIO. Convex transducer of 3.5-5MHZ. Comparation lengths  with Rosenbaum curve´s. Descriptive and inferential analysis with square chu test, Fishers exact test, unpaired test and Pearsons correlation coefficient. 

Results:

66% were male.The mean and 95% CI of: EG was 30 (s) (29.6;30.9); PN 1344 g (1259;1429). At control age was 4.41 years, P 17.3 (15.5;19.1), BMI 15.4 (14.7;16.2).  PAS 102 (98;105), PAD 63 (60;66). They had high blood pressure (HBP); pre HTAS 9%, HTAS slight 19%, HTAS severe 2% and pre HTAD 7%, HTAD mild 28%, HTAD severe 9%. The means of laboratory markers, Cr: 0.5 (0.46;0.56), FG 78 (70;86), MAU / Cru 827 (159;1495). It was found that 21% had Cr> 0.6, FG <90 74% and> 120, 4%. MAU/Cru (n=21), altered 80%. The means of LR (mm) of RD (LRD) was 69 (67;72) and RI (LRI) 71 (68;74). 72% and 27% were below and above the mean for age, respectively. LR did not significantly associate Cr, FG, altered MA, and HBP. The renal measures were correlated as continuous variables with the variables of renal function, SBP and DBP, age, EG and PN. Positive linear correlation was found between VA, VR, LA and VP. And negative correlation with LR.

 

 

Conclusions:

This NNP population aged 1 to 7 years had high frequencies of high Cr, altered GFR and kidney size lower than the values ​​for age. All of them are risk factors for future kidney health. Cohort studies of older children are necessary.

Keywords. Premature Kidney measures