ESPN 51th Annual Meeting

ESPN 2018


 
Early Determination Of Renal Injury In Children With Solitary Functioning Kidney
OZGUL GORUR 1 AYSUN KARABAY BAYAZIT 1 BAHRIYE ATMIS 1 ENGIN MELEK 1 CAGRI OZCELIK 1 TAMER CEVAT INAL 2 SALIH CETINER 2 ALI ANARAT 1

1- CUKUROVA UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRIC NEPHROLOGY
2- CUKUROVA UNIVERSITY, BALCALI HOSPITAL, CENTRAL LABORATORY
 
Introduction:

 Patients with congenital unilateral renal agenesis are at risk for developing proteinuria, hypertension and renal failure in their long-term follow-up. In this study we aimed to determine early findings of glomerular hyperfiltration and renal injury in children with solitary functioning kidney.

Material and methods:

 Forty-four patients with URA and 43 age and sex matched healthy controls, with an age of >5 years, who were regularly followed up at Çukurova University between January 2016 and December 2017 were included in the study. Fourteen patients aged between 5-9 years were in group1; 17 patients aged between 10-14 years were in group2; 13 patients aged between 15-19 were in group3. Renal function tests urinary MA/Cr, UNGAL/Cr and UIL 18/Cr levels were measured. Kidney size was assessed according to the age-specific percentile chart.

Results:

 There were no difference between groups in terms of renal function tests, renal size, MAP and UMA/cr. No statistical difference was found in  UNGAL/cr between patient and control groups. In patient group UIL-18/Cr median value was 0.30pg/mg at ages 5-9, 0,84 pg/mg at ages 10-14 and 21.13pg/mg at ages of 15-19. In the control group these median values were as follows; 0,33 pg/mg in group 1 at ages 5-9, 0,20 pg/mg in group 2 at ages 10-14 and 0,18 pg/mg in group 3 at ages 15-19. Urine IL-18/Cr ratio was statistically significantly different between patient and control groups with the median value of 17.70 in patient group and 2,79 in control group (p values were p = 0.014 and p = 0.002, respectively).

Conclusions:

 The increase in urinary IL-18/Cr ratios, which is one of the early markers of renal damage, with the patients age increase but not in the healthy controls, can be regarded as an early indication of glomerular injury which begin in the second decade of life.