ESPN 51th Annual Meeting

ESPN 2018


 
CAN URINARY URIC ACID/CREATININE RATIO BE USED AS A SURROGATE FOR RENAL SCARRING IN VESICOURETERIC REFLUX?
AHMET MIDHAT ELMACI 1 MUHAMMET İRFAN DÖNMEZ 2 LUTFI SALTUK DEMIR 3

1- KONYA DR.ALI KEMAL BELVIRANLI WOMENS MATERNITY AND CHILDRENS HOSPITAL
2- KONYA TRAINING AND RESEARCH HOSPITAL
3- NECMETTIN ERBAKAN UNIVERSITY MERAM FACULTY OF MEDICINE
 
Introduction:

Increased urinary excretion of uric acid has been shown to be associated with vesicoureteric reflux (VUR). The aim of this study is evaluate if urinary uric acid/creatinine ratio can be used as a surrogate for renal scarring in VUR.

Material and methods:

Retrospective chart analysis was made to identify patients who were diagnosed with VUR. Those with secondary VUR, <3 years of age, and inadequate evaluation were excluded. Age, gender, VUR status, dimerkaptosuccinic acid(DMSA) scintigraphy findings, microalbuminuria, presence of hypertension and body mass index values were noted. Uric acid, calcium and creatinine (Cr) levels for both urine and serum were measured. Urinary uric acid/Cr and calcium/Cr ratios were assessed for age. Backward logistic regression analysis was used for determining any predictors.

Results:

A total of 76 patients were eligible for the study between 2011 and 2017. Mean age was 8.2±3.7 years. There were 49 females and 27 males. Fifty-one patients had renal scars while 25 had no scars. Microalbuminuria was present in 22 patients. Hypertension was detected in 5 patients. Hyperuricosuria was found in 23 (30.7%) patients while hypercalciuria was found only in 1 patient (1.3%). There was no correlation between urinary uric acid/Cr and renal scarring, microalbuminuria and hypertension. Also, no correlation was found between urinary calcium/Cr levels and aforementioned parameters (p values >0.05, for all). Urolithiasis was present in 8 patients (10.7%) however only 3 patients with hyperuricosuria (13%) had urinary stones.

Conclusions:

Our results indicate not only urinary uric acid/Cr but also, urinary calcium/Cr levels would not be used as surrogate for renal scarring in vesicoureteric reflux.