ESPN 51th Annual Meeting

ESPN 2018


 
Gentamicin safety in the treatment of children with acute pyelonephritis and urinary tract infection
AGNė MATUSEVIčIENė 1 JūRATė MASALSKIENė 1 ŠARūNAS RUDAITIS 1 DIANA DOBILIENė 1

1- LITHUANIAN UNIVERSITY OF HEALTH SCIENCES, DEPARTMENT OF PEDIATRICS
 
Introduction:

Set gentamicin nephrotoxic and ototoxic effects in the treatment of children with acute pyelonephritis (APN) or other urinary tract infection (UTI).

Material and methods:

63 children treated with gentamicin were investigated. APN was diagnosed according to childhood UTI diagnosis and treatment guidelines in Lithuania. Gentamicin was given 4 mg/kg/d once daily. Before  third and the seventh gentamicin dose concentrations of gentamicin, BUN and creatinine in the blood, hearing audiologic examination, otoacoustic emissions and impedansometria were done.

This study was approved by LUHS ethics committee. Data analysis was performed with the IBM SPSS 20 statistics pack. Data was considered statistically significant with p <0.05.

Results:

 APN was diagnosed in (83.3 %) in cases, more often in girls (81.0 %). E.coli was the main pathogen (69.8 %), which sensitivity to gentamicin was 100 %. Gentamicin concentration was in therapeutic ranges in 95.2 % before third dose and 81.0 % before seventh dose (p>0.05). 4 (6.3 %) had toxic concentration (p >0.05). 9.5 % patients gentamicin was changed to another drug. Renal function, impedansometria remains stable. 1 patient had worsening in audiologic examination and 1 in otoacoustic emissions before seventh dose.

Conclusions:

Only two patients had ototoxic effects of gentamicin and none of them had nephrotoxic drug effects. The use of gentamicin in recommended doses is safe, toxicity is rare.