ESPN 51th Annual Meeting

ESPN 2018


 
HOSPITALIZATIONS AFTER KIDNEY TRANSPLANTATION IN CHILDREN
ZEYNEP BIRSIN ÖZÇAKAR 1 NILGÜN ÇAKAR 1 EDA DIDEM KURT ŞÜKÜR 1 ECE MEKIK 1 FATOŞ YALÇINKAYA 1

1- ANKARA UNIVERSITY MEDICAL FACULTY, PEDIATRIC NEPHROLOGY, ANKARA, TURKEY
 
Introduction:

Renal transplantation is associated with improved survival rate in patients with end stage renal disease. However, ongoing hospitalizations after transplantation is an important problem and could impair life quality of these patients. The aim of this study was to investigate the frequency, causes and risk factors of hospitalizations in children after renal transplantation.

Material and methods:

We retrospectively reviewed the files of renal transplanted children between 2008 and 2018 in our center. Results are given as median (minimum-maximum) or proportion. Comparison between two groups for the non-normally distributed variables was assessed by Mann Whitney U test. A p value less than 0.05 was considered significant.

Results:

Sixty seven patients (41 male, 49 living related transplantation) were included. Median age at transplantation was 13,75 (2,25-19,5) years and follow up period was 44 (3-106) months. A total of 321 hospitalizations were identified in 60 patients and the rate of hospitalization was found to be 1/10.3 patient months. Median hospitalization rate was 3 (0-31) and 9 patients had >10 hospitalizations. Infection was the leading cause of hospitalization (68.5%); 50 patients had a total of 220 and the rate of infection related hospitalization was 1/15 patient months. Urinary tract (32.7%) and upper respiratory tract infections (23.6%) were the most common causes of infection related hospitalizations. Age at transplantation was inversely correlated with the number of hospitalizations and infection related ones. Patients treated with induction therapies (bazilixumab/antithymocyte globulin; n=25) were more frequently hospitalized and had more infection related hospitazations (p<0.05).

Conclusions:

Hospitalizations, especially infection related ones were frequently encountered in renal tranplanted children. Clinicans should find solutions in order to decrease these rates and improve quality of life in children with transplantation.