ESPN 51th Annual Meeting

ESPN 2018


 
Aetiologies of chronic kidney disease in Tunisian children: study of 161 cases
SAMEH MABROUK 1 SALSABIL NOUIR 1 HOUDA AJMI 1 FADWA MAJDOUB 1 NOURA ZOUARI 1 FERDOUSSA HIBO 1 JALEL CHEMLI 1 SAIDA HASSAYOUN 1 SAOUSSEN ABROUG 1

1- Departement of pediatrics - UNIVERSITY HOSPITAL SAHLOUL (Sousse - Tunisia)
 
Introduction:

 

Chronic kidney disease (CKD) in children is a major health problem worldwide. This medical condition is relatively rare, its region-specific incidence and characteristics are still not well defined. Etiologies of CKD may vary between countries since climate, cultures, genetics and environmental factors are

Material and methods:

 

Retrospective analysis of medical charts of children diagnosed with CKD and managed in the department of paediatric nephrology at the University hospital of Sahloul (Sousse – Tunisia), during a 1 years period (2005- 2015)

Results:

 

161 patients were included, 91 boys and 70 girls. Consanguinity rate was 62.1%. Mean age at CKD diagnosis was 7,5 ± 5,1 years. At diagnosis, 52 of patients have already reached ESRD. CAKUT were the most prevalent causes of CKD in our series (47,2%). VUR represented 34.1% followed by neurogenic bladder (16.1%), megaureter (13%) and posterior uretric valves (5.6 %). The second group of etiologies were hereditary diseases in 33.5 % of cases. In this group, the main 2 causes were nephronophtisis and primary hyperoxaluria type on in 12.4% and 11.8% respectively. The third most frequent causes were glomerulopathies (11.8%). 3.7 % remained without identified cause.

Conclusions:

 

Among Tunisian children the hallmark feature of etiologies of  CKD, is the important place of hereditary causes particularly nephronophtisis and primary hyperoxaluria type I.