ESPN 51th Annual Meeting

ESPN 2018


 
Idiopathic nephrotic syndrome in children:our experience
SNEZANA ZULIC 1 NEDIMA ATIC 1

1- UNIVERSITY CLINICAL CENTER TUZLA, BIH
 
Introduction:

The retrospective study was conducted in order to analyse the clinical and histopathological features in childhood idiopathic nephrotic syndrome (INS).

 

Material and methods:

The study included 44 children aged up to 15, who were diagnosed to have INS. The research was conducted at our Department of Paediatrics, in the period between 2000 to 2015. Clinical and laboratory features, as well as indications for renal biopsy and histopathology findings were all analyzed.

 

Results:

In total, 18 children were diagnosed as minimal change nephrotic syndrome (MCNS) based on their initial presentation, laboratory findings and clinical course. Kidney biopsy was performed in the remaining 26 children. Mesangial proliferative glomerulonephritis (MEPGN) was the most common diagnosis, present in 10 (38,5%) of all biopsies performed, focal segmental glomerulosclerosis (FSGS) was found in 7 (26,9%), membranoproliferative glomerulonephritis (MPGN) in 2 (7,7 %) and minimal change nephrotic syndrome (MCNS) in 3 (11,5%). The biopsy was negative in 4 (15.4%) patients.

 

Conclusions:

The results showed that MCNS is the most common cause of INS. MEPGN and FSGS is found to be the most common biopsy-proven histopatologic finding in our study. Although the sample is not representative, this analysis provides insight into the common occurence of INS in our environment.