ESPN 51th Annual Meeting

ESPN 2018


 
Evaluation of respiratory function of children with nephrotic syndrome by impulse oscillometry and spirometry
FATIH KILCI 1 Z. SEDA UYAN 2 MEHTAP ÇELAKIL 1 BURCU BOZKAYA YÜCEL 1 KENAN BEK 1

1- KOCAELI UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF PEDIATRIC NEPHROLOGY
2- KOÇ UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF PEDIATRIC CHEST DISEASES
 
Introduction:

 Pulmonary functions may be affected in nephrotic syndrome (NS) Impulse oscillometry (IOS), a novel method showing  airway problems, requires passive patient cooperation and is applicaple even in small children. We evaluated pulmonary functions of children with NS by IOS and its correlation with spirometry.

Material and methods:

 55 NS patients (aged 3-18 years), and 40 healthy children were included in the study. Of patients, 11 were in first episode, 21 in relapse and 23 in remission. IOS was applied to all subjects and spirometry to 30 patients and 15 controls.

Results:

No difference was found between IOS and spirometry parameters of the first episode and relapse patients. The R ​​(R5%, R10%, R5-20) and AX and Z5% values of IOS in patients with first episode or relapse were higher than controls, while the X values ​​(X10 and X15) were lower than the control group. Spirometric indices of FEV1%, FEV1/FVC, PEF% and MEF25-75% were lower in first episode or relapse patients than controls. While significant difference was found for AX, R5-20, X20% and MEF25-75% parameters between patients in attack (first episode or relapse) and remission; no difference was found between remission and control group except X15%.The correlation between IOS and spirometric indices were as follows:  [R5%, R10%, R15%, X10%] with  [X15% FEV1%]; [R5%, R5-20, X15%] with [FEV1 / FVC];[X10%] with[FVC] and [AX , R5%, R10%, R5-20, Fres and Z5%]  with [MEF25-75] correlated negatively; and [X10, X15]  with [MEF25-75] correlated positively.

 

Conclusions:

Our preliminary results indicated obstructive airway disease limited to distal and small airways during attack in NS. However; they were normal in remission. Given its good correlation with spirometry, IOS seems relaiable in children with NS.