ESPN 51th Annual Meeting

ESPN 2018


 
DOES SERUM FIBROBLAST GROWTH FACTOR-23 PLAY A ROLE IN THE PATHOGENESIS OF HYPERTENSION IN OBESE CHILDREN?
Hatice Kevser Ayaz 1 Ahmet Irdem 2 Diğdem Bezen 3 Hasan Dursun 4

1- Health Sciences University, Okmeydani Education and Research Hospital, Department of Pediatrics
2- Health Sciences University, Okmeydani Education and Research Hospital, Department of Pediatric Cardiology
3- Health Sciences University, Okmeydani Education and Research Hospital, Department of Pediatric Endocrinology
4- Health Sciences University, Okmeydani Education and Research Hospital, Department of Pediatric Nephrology
 
Introduction:

The aim of this study was to determine the relationship between hypertension and serum fibroblast growth factor (FGF-23) levels in obese children aged 6-18 years who are referred to pediatric nephrology and pediatric endocrinology outpatient clinics. The second aim of this study was to determine the relationship between FGF-23 and biochemical markers which may be indicative of hypertension.

Material and methods:

From October 2016 to March 2017, 40 hypertensive and 40 normotensive patients with obesity between the ages of 6 and 18 who admitted to Pediatric Nephrology and Pediatric Endocrinology Outpatient Clinics were included in the study. The laboratory data of the patients at the time of admission were recorded retrospectively from their files. 24-hour ambulatory blood pressure monitoring was performed and blood pressure data was recorded. Blood serum samples were stored at -80°C and serum FGF-23 levels of all patients were measured at the same time with the ELISA method.

Results:

The levels of FGF-23 in hypertensive patients were not significantly different from normotensive patients. In hypertensive patients, FGF-23 was positively associated with 24-hour mean diastolic blood pressure (p=0.021) and mean daytime diastolic blood pressure (p=0.013). Ambulatory blood pressure monitoring parameters were found to be positively correlated with serum sodium in normotensive patients. In hypertensive patients, serum creatinine was positively correlated with ambulatory blood pressure monitoring parameters. In all patients, triglyceride was positively associated with FGF-23 (p=0.019). In normotensive patients, FGF-23 was positively correlated with total cholesterol (p=0.035) and calcium (p=0.049).

Conclusions:

The levels of FGF-23 was positively associated with diastolic blood pressure in this study. This result suggests that FGF-23 may play a role in the pathogenesis of hypertension, but may primarily affect diastolic blood pressure.