ESPN 51th Annual Meeting

ESPN 2018


 
THE ROLE OF SOME BIOLOGICAL MARKERS OF OBESITY IN CHILDREN WITH CARDIOVASCULAR RISK
MARTINA MEDVED 1 LAURA OJSTERšEK 1 NATAšA MARčUN VARDA 1

1- DEPARTMENT OF PAEDIATRICS, UNIVERSITY MEDICAL CENTRE MARIBOR, LJUBLJANSKA 5, 2000 MARIBOR, SLOVENIA
 
Introduction:

The occurrence of cardiovascular diseases like hypertension steadily increases with body mass index (BMI). As the latter is not the best indicator of obesity, we aim to evaluate some other biological markers of obesity, namely leptin, ghrelin and adiponectin, as potential early cardiovascular risk markers in some children with cardiovascular risk.

Material and methods:

The study included a sample of 337 children, adolescents and young adults, aged between 8 months and 22 years, who were treated at the Department of Paediatrics, University Medical Centre Maribor. The participants were divided into four groups: obese children with hypertension, normal weight children with hypertension, children with elevated lipids and a control group of healthy children. Some clinical and biochemical parameters as well as biological markers of obesity, leptin, ghrelin and adiponectin, have been measured according to standard procedures.

Results:

Ghrelin and adiponectin have been found to have a strong negative statistically significant correlation with BMI in the three observed groups, but not in the control group. In leptin, however, a strong positive statistically significant correlation with BMI in all four groups has been determined. In the obese hypertensive patients, in comparison to controls, all three markers were significantly different, in the group of children with elevated lipids the difference in both leptin and ghrelin was found, and in normal weight hypertensive patients, only the difference in ghrelin was noted.

Conclusions:

In research groups, significant differences in investigated biological markers of obesity have been found indicating that they might be useful markers for identifying groups of patients that are the most vulnerable, with ghrelin being the most promising. In addition, significant correlation with BMI was found.