ESPN 51th Annual Meeting

ESPN 2018


 
Outcome after renal transplantation for focal segmental glomerulosclerosis in children
FERJANI MARYEM 1 HAMMI YOUSRA 1 BOUSETTA ABIR 1 MAYEL MARWA 1 JELLOULI MANEL 1 GARGAH TAHAR 1

1- DEPARTMENT OF PEDIATRIC NEPHROLOGY OF CHARLES NICOLLE, TUNIS,TUNISIA
 
Introduction:

 

Focal segmental glomerulosclerosis (FSGS) leads to steroid-resistant nephrotic syndrome and to renal failure.Transplanataion is followed by reccurence in 30% of patients.Graft survival is decreased in children witn FSGS compared with other primary diagnosis,and the impact is greatest in recipients of living donor transplants.In this study,we present our experience with renal transplantation in Tunisian children with biopsy proven FSGS.

Material and methods:

 

Medical records of 6 children with biopsy proven non-familial FSGS were reviewed retrospectively.Data collected included the demographic profile of patients ,time taken to reach end-stage renal-disease,timing of transplanataion,details of immunosupression,complications,recurrence if any,measures taken in case of recurrence,graft survival and patient survival.

Results:

 

Six children(4 males,2 females),with FSGS had a renal transplant during the fifteen-year period.The media nage of onset of disease was 5.5 (range :3-11years).While the median age at the time of transplanataion was 11,3 years (range :7.5-20years).Four children had primary steroid resistance and two patients developed late steroid resistance.The mean time to reach end-stage renal disease was 3.5 years.Five children recieved a kidney from a deceased donor and one child from living donor.The mean age of the donors was 37.5 years .Recurrens developed immediately in one patient who further developed fatal cytomegalovirus encephalitis.One patient died seven months post-transplant because of sepsis.One patient lost his graft owing to recurrence.

Conclusions:

 

Although the number of patients is quite small,our recurrence rate was compatible with previous reports.