ESPN 51th Annual Meeting

ESPN 2018


 
Markers of kidney damage in children with Henoch-Schönlein Purpura
KATARZYNA DYGA 1 MAJKA JASZCZURA 3 PIOTR ADAMCZYK 2 ELZBIETA SWIETOCHOWSKA 4 ALEKSANDRA BRYLKA 1 EDYTA MACHURA 2 MARIA SZCZEPANSKA 2

1- DEPARTMENT OF PEDIATRIC NEPHROLOGY WITH DIALYSIS DIVISION FOR CHILDREN, ZABRZE, POLAND
2- DEPARTMENT AND CLINIC OF PEDIATRICS, SMDZ IN ZABRZE, SUM IN KATOWICE, POLAND
3- Department of Pediatrics. Zabrze, Poland
4- DEPARTMENT OF MEDICAL AND MOLECULAR BIOLOGY, SMDZ IN ZABRZE, SUM IN KATOWICE, POLAND
 
Introduction:

Henoch- Schönlein Purpura (HSP) is the most common type of systemic vasculitis in childhood. In general HSP is considered to be benign and self-limited however renal involvement could create the chronic consequences. The aim of the study was to estimate the frequency and severity of kidney disorders in patients with Henoch- Schönlein Purpura and to find a marker which facilitates the identification of the children with the higher risk of renal involvement.

Material and methods:

Medical records of 52 patients, with diagnosis of HSP treated in the Dpt of Pediatrics were evaluated. The clinical, anthropometric parameters and laboratory test results including concentrations of the markers of kidney damage in serum and urine were analyzed.

Results:

The kidney disorders were observed in 40% of patients in the initial period of HSP. In 11,5% of them isolated hematuria was diagnosed, in  23%  - proteinuria with hematuria and in 5,8% increased serum concentration of creatinine. In 56% of children the renal involvement was noticed until 6 months. The statistically significant (p<0,05) difference with the concentration of  NGAL (neutrophil gelatinase-associated lipocalin), KIM-1 (kidney injury molecule-1) and  L-FABP (kidney injury molecule-1) in  serum and urine in the initial period and after 6 months was observed. 

Conclusions:

Markers of kidney damage such as NGAL, KIM-1 and L-FABP contribute with renal involvement in children with HSP.