ESPN 51th Annual Meeting

ESPN 2018


 
TEN YEAR FOLLOW-UP RESULTS OF CHILDREN DIAGNOSED WITH HENOCH SCHÖNLEIN PURPURA IN TRAKYA REGION
AYŞEGÜL ÖRENCİK 1 NEŞE ÖZKAYIN 1

1- TRAKYA UNIVERSITY
 
Introduction:

Henoch-Schönlein purpura (HSP) is a self-limiting leukocytoclastic vasculitis which presents itself with skin involvement, arthritis or arthralgia, gastrointestinal tract (GI) involvement, mild or severe renal involvement. The aim of this study was to evaluate the demographic features, clinic, laboratory, and treatment analysis of HSP in children.

Material and methods:

The files of 235 cases followed by HSP in the Department of Pediatric Nephrology, Trakya University Medical Faculty between April 2005 and December 2015, were analysed.

Results:

Among 235 HSP patients, 122 (51.9%) were males, 113 (48.1%) were females. The mean age was 7.32±3.63. The distribution rate of the patients according to the seasons was 33.6% in winter, 30.2% in autumn, 23.4% in spring and 12.8% in summer. Upper respiratory tract infection was present in 164 (84.5%) patients, gastroenterit in 12 (6.1%) patients, lower respiratory infection in 10 (5.1%) patients, akut otitis media in 4 (2%) patients, urinary tract infection in 2 (1.03%) patients, chickenpox in 1 patients and dental abscess in 1 patients. 234 (99.6 %) patients had skin, 161 (68.5%) had joint, 128 had GI and 126 had renal involvement. Skin rash was most commonly seen in the lower limbs (99.6%). There was abdominal pain in 117 (91.4%) of patients, occult blood in stool in 93 (72.6%), vomiting in 36 (28.1%), melena in 14 (10.9%). Among the patients who had renal involvement 81 patients had (64.2%) proteinuria, 75 patients (59.6%) had hematuria and 60 patients had hematuria and proteinuria. High ESR levels were reported in 148 patients (63%), however CRP levels were increased only in 18 patients (7.7%). We observed that leukocytosis was 44 (18.7%). While there was no difference between the age groups when compared to system involvement; the joint involvement was found to be statistically significantly higher in females than in males . When the relation between system involvement and high leukocyte count was evaluated, it was found to be statistically higher in patients with GIS and renal involvement. High ESR in the group with joint involvement, and CRP increasement in the group with renal involvement were found to be statistically significantly higher. In patients with renal involvement ,GI involvement was found to be higher than those without renal involvement.

Conclusions:

Upper respiratory tract infection is the most important triggering factor which is seen mostly during winter season.It is accompanied by many systemic involvements especially skin involvement. Prognosis is generally good. However, long term follow up had to be made for the complications especially GI and renal involvement.