ESPN 51th Annual Meeting

ESPN 2018


 
NEONATAL ACUTE RENAL FAILURE ASSOCIATED WITH MATERNAL EXPOSURE TO ANGIOTENSIN II RECEPTOR ANTAGONIST: A CASE REPORT.
GURDEEP SINGH DHOORIA 1

1- DAYANAND MEDICAL COLLEGE AND HOSPITAL, LUDHIANA, PUJAB, INDIA
 
Introduction:

 

Angiotensin II receptor blocker (ARBs) are commonly used antihypertensive drug at present. Toxic effects of angiotensin II receptor blocker have been described on human fetus.

Material and methods:

 We report a case of oliguric renal failure in a three day neonate with no features of obstructive uropathy, sepsis or perinatal asphysia. Renal ultrasound and renal Doppler were normal and UTI was ruled out. History of maternal consumption of losartan, an angiotensin II receptor blocker (ARB) during third trimester of pregnancy for control of PIH was found.  The neonate was treated conservatively and oliguria and renal failure improved after  two weeks and was discharged in a stable condition.

Results:

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Conclusions:

 

Like ACE inhibitors, ARB should not be prescribed during all trimester of pregnancy and breastfeeding. Long term follow-up of these patients is necessary because of high risk of persistent and secondary renal insufficiency.