ESPN 51th Annual Meeting

ESPN 2018


 
Retrospective evaluation of hematological parameters in hypertensive children with non-dipper and dipper status
NURAN CETIN 1 ASLI KAVAZ TUFAN 1

1- DEPARTMENT OF PEDIATRIC NEPHROLOGY, FACULTY OF MEDICINE, ESKISEHIR OSMANGAZI UNIVERSITY, TURKEY
 
Introduction:

Systemic inflammation and platelet activation have an important role in the development of target organ damage in non-dipper hypertension. In this study, we aimed to investigate the association between ambulatory blood pressure monitoring (ABPM) values and hematological parameters which reflect inflammation and platelet activation in children with dipper and non-dipper hypertension. 

Material and methods:

The ABPM data from children between 5 and 18 years were used in this study. According to ABPM results, the patients were divided into three groups:  (non dipper hypertension, dipper hypertension, and normotensive group). The relationship between ABPM data and neutrophil lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), neutrophil and platelet counts were investigated.

Results:

The ABPM data of 153 outpatients were included in this study (61 non-dipper hypertensive, 28 dipper hypertensive, 64 normotensive). A significant positive correlation was found between MPV, and WBC with neutrophil count (r=0.389, p=0.000 and r=0.346, p=0.001, respectively) in patiens with hypertension. The patients with non-dipper and dipper status had significantly higher neutrophil count than in normotensive group (p=0.026, p=0.003, respectively). Also, MPV levels were significantly higher in non-dipper and dipper groups than those in normotensive group (p=0.014, p=0.001, respectively). Logistic regression analysis showed that MPV, platelet count and PLR were significantly associated with presence of nondipper status in patients with ambulatory hypertension (p=0.023, p=0.008, p=0.046, respectively).

 

Conclusions:

Inflammation might play a role of the development of hypertension in children. The platelet activation might be an indicator for increased risk of atherosclerosis in children with hypertension.