ESPN 51th Annual Meeting

ESPN 2018


 
SERUM GELSOLINE LEVELS AND OXIDATIVE DAMAGE IN CHILDREN WITH IGA VASCULITIS (HENOCH SCHONLEIN PURPURA)
Burcu Danacı 1 Funda Baştuğ 2 Çiğdem Karakükçü 3 Hülya Nalçacıoğlu 2 Sibel Yel 2 Yasemin Altuner Torun 1

1- SBU Kayseri Educational and Research Hospital, Department of Pediatrics
2- SBU Kayseri Educational and Research Hospital, Department of Pediatric Nephrology
3- SBU Kayseri Educational and Research Hospital, Department of Biochemistry
 
Introduction:

The aim of this study is to investigate levels of serum gelsolin (pGSN), is an actin-binding protein and oxidative stress markers during active and remission periods of children with IgA vasculitis, and whether there is a difference in pGSN and oxidative stress markers in different organ involvement of IgA vasculitis. 

Material and methods:

30 patients with IgA vasculitis (19 males, 11 females) and 30 healthy children were included in the study. Children with IgA vasculitis were evaluated during active and remission periods (IgAV-active and IgAV-remission groups). IgAV-active group were evaluated in terms of first complaints, systemic involvement and the laboratory findings. Levels of pGSN, oxidative stress markers [superoxide dismutase (SOD), glutathione peroxidase (GPx) malondialdehyde (MDA)] of IgAV-active group was compared with IgAV-remission and control groups.

Results:

The mean age of the patients with IgA vasculitis was 9.21 ± 4 years (1.5-16.8 years) and 63.3% of  patients were male, 36.7% were female (M/F: 1.7/1) . Organ involvement was as follow; skin in all cases, joint 83.3%, gastrointestinal system 56.7%, renal 10% and scrotal nvolvement 10% positive in the patients.

pGSN levels in the IgAV-active and IgAV-remission groups were significantly lower than the control group (p <0.001). The pGSN level in the IgAV-remission group was also lower than in the IgAV- active group (p <0.02). pGSN level did not differ in different organ involvement.

GPx levels were significantly higher in the IgAV-active group than in the IgAV-remission and control group (p <0.001). It was also was significantly higher in the IgAV-remission group compared to the control group (p<0.05). There was no difference between the groups interms of SOD and MDA values.

Conclusions:

To our knowledge, this is the first randomized controlled study to investigate the relationship between pGSN and IgA vasculitis. Several studies have shown that pGSN is low in the inflammatory process and a similar finding has been found in our study. There are experimental studies in which pGSN can be used for treatment.

Our study showed that pGSN levels are low during the active phase of patients with IgA vasculitis. With this finding, "Does the treatment of pGSN at the beginning of the disease affect the prognosis of the disease?" has brought the question to mind. When our study is supported by studies with more patients in this regard, perhaps it will be able to contribute to the treatment of patients with IgA vasculitis in the future