ESPN 51th Annual Meeting

ESPN 2018


 
Urinary procollagen III aminoterminal propeptide and β-catenin as diagnostic biomarkers of renal fibrosis in solitary functioning kidney.
KATARZYNA TARANTA-JANUSZ 1 ANNA MOCZULSKA 2 HANNA NOSEK 3 JOANNA MICHALUK-SKUTNIK 1 MARK KLUKOWSKI 4 KATARZYNA WERBEL 1 NATALIA WISNIEWSKA 1 ANNA WASILEWSKA 1

1- DEPARTMENT OF PEDIATRICS AND NEPHROLOGY, MEDICAL UNIVERSITY OF BIALYSTOK, POLAND
2- DEPARTMENT OF PEDIATRIC NEPHROLOGY, JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE, CRACOW, POLAND
3- DEPARTMENT OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, REGIONAL SPECIALIZED CHILDREN’S HOSPITAL IN OLSZTYN, POLAND
4- DEPARTMENT OF PEDIATRICS, GASTROENTEROLOGY AND ALLERGOLOGY, MEDICAL UNIVERSITY OF BIALYSTOK, POLAND
 
Introduction:

A solitary functioning kidney (SFK) represents a particular entity in nephrology, requiring certain attention from the specialist. Studies on long-term outcomes of children with a SFK are rather controversial. A SFK represents a challenge when renal impairment occurs. Over the last decade, several promising early biomarkers of renal damage have been identified in the urine.

Material and methods:

We aimed at evaluating urinary levels of procollagen III aminoterminal propeptide(PIIINP) and β-catenin and the relationship between these markers and clinical and laboratory variables in children with a solitary functioning kidney (SFK). UPIIINP ELISA was performed using a commercially available immunoassay kit and expressed as picograms per milliliter (pg/mL). Urinary β-catenin ELISA was performed using a commercially available kit. Urinary β-catenin concentration was expressed as picograms per milliliter (pg/mL).

Results:

The urinary values of PIIINP (UPIIINP) were significantly increased in patients with SFK versus controls (p<0.01). Our analysis revealed no significant differences in urinary β-catenin levels between the SFK patients and control subjects (p>0.05). Onlyurinary PIIINP levels were correlated to renal function tests, such as serum creatinine, urea, uric acid, and estimated glomerular filtration rate (p<0.05).

Conclusions:

An increased urinary level of PIIINPmay indicate early kidney impairment in children with a SFK. β-cateninurinary does not seem to play any important role as a marker of renal function in children with SFK. Further long-term studies are required in order to evaluate the clinical usefulness of these markers and their predictive value for chronic kidney disease progression.